Entangling macroscopic diamonds at room temperature: Bounds on the continuous-spontaneous-localization parameters

A recent experiment [K. C. Lee et al., Science 334, 1253 (2011)] succeeded in detecting entanglement between two macroscopic specks of diamonds, separated by a macroscopic distance, at room temperature. This impressive results is a further confirmation of the validity of quantum theory in (at least parts of) the mesoscopic and macroscopic domain, and poses a challenge to collapse models, which predict a violation of the quantum superposition principle, which is the bigger the larger the system. We analyze the experiment in the light of such models. We will show that the bounds placed by experimental data are weaker than those coming from matter-wave interferometry and non-interferometric tests of collapse models.Comment: 7 pages, 3 figures, v2: close to the published version, LaTe

Generalized seniority scheme in light Sn isotopes

The yrast generalized seniority states are compared with the corresponding shell model states for the case of the Sn isotopes $^{104-112}$Sn. For most of the cases the energies agree within 100 keV and the overlaps of the wave functions are greater than 0.7.Comment: 8 pages, revtex. Submitted to Phys. Rev.

Possible Photometric Evidence of Ejection of Bullet Like Features in the Relativistic Jet source SS433

SS433 is well-known for its precessing twin jets having optical bullets inferred through {\it spectroscopic} observation of $H_\alpha$ lines. Recently, Chakrabarti et al. (2002) described processes which may be operating in accretion disk of SS433 to produce these bullets. In a recent multi-wavelength campaign, we find sharp rise in intensity in time-scales of few minutes in X-rays, IR and radio waves through {\it photometric} studies. We interpret them to be possible evidence of ejection of bullet-like features from accretion disks.Comment: 9 latex pages with five figure

Lifetime measurements of high-spin states in Ag-101 and their interpretation in the interacting boson fermion plus broken pair model

Lifetimes of 20 high spin states in Ag-101 in the range between 0.2 and 200 ps have been measuredand interpreted within the boson fermion plus broken pair model

Broken pairs and evolution of collectivity in the A≊140 mass region: High spin states of the ^138_60Nd_78 nucleus

An in-beam γ-ray study performed with the 121Sb(19F,4n) reaction has established the high spin level structure of the N=78 nucleus 138Nd. States up to I=21ħ and 8.5 MeV excitation energy have been indentified. High spin states are described in the framework of the cranking model and of the interacting boson model with broken pairs. The calculations reproduce levels up to I=18ħ including the two 10+ states which, from the feeding cascades, are identified as the νh^-1_11/2 and πh^2_11/2 excitations. Cranked Strutinsky type calculations predict opposite shapes for the two different types of excitations

Broad band variability of SS433: Accretion disk at work?

We present broad band power spectra of variations of SS433 in radio, optical and X-ray spectral bands. We show that at frequencies lower than 1e-5 Hz the source demonstrates the same variability pattern in all these bands. The broad band power spectrum can be fitted by one power law down to frequencies ~1e-7 Hz with flattening afterwards. Such a flattening means that on time scales longer than ~1e7 sec the source variability becomes uncorrelated. This naturally leads to the appearance of quasi-poissonian flares in the source light curve, which have been regularly observed in radio and optical spectral bands. The radio flux power spectrum appears to have a second break at Fourier frequencies ~1e-5 Hz which can be caused by the smearing of the intrinsic radio variability on timescale of the light-crossing time of the radio emitting region. We find a correlation of the radio and optical fluxes of SS433 and the radio flux is delayed by about ~2 days with respect to the optical one. Power spectra of optical and X-ray variabilities continue with the same power law from 1e-7 Hz up to ~0.01-0.05 Hz. The broad band power spectrum of SS433 can be interpreted in terms of self-similar accretion rate modulations in the accretion disk proposed by Lyubarskii (1997) and elaborated by Churazov et al. (2001). We discuss a viscous time-scale in the accretion disk of SS433 in implication to the observed broad band power spectrum.Comment: 8 pages, 2 figures. Submitted to A&

HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope

HIV-1 envelope (Env) mimetics are candidate components of prophylactic vaccines and potential therapeutics. Here we use a synthetic V3-glycopeptide (“Man9-V3”) for structural studies of an HIV Env third variable loop (V3)-glycan directed, broadly neutralizing antibody (bnAb) lineage (“DH270”), to visualize the epitope on Env and to study how affinity maturation of the lineage proceeded. Unlike many previous V3 mimetics, Man9-V3 encompasses two key features of the V3 region recognized by V3-glycan bnAbs—the conserved GDIR motif and the N332 glycan. In our structure of an antibody fragment of a lineage member, DH270.6, in complex with the V3 glycopeptide, the conformation of the antibody-bound glycopeptide conforms closely to that of the corresponding segment in an intact HIV-1 Env trimer. An additional structure identifies roles for two critical mutations in the development of breadth. The results suggest a strategy for use of a V3 glycopeptide as a vaccine immunogen

Recombinant HIV Envelope Proteins Fail to Engage Germline Versions of Anti-CD4bs bNAbs

Vaccine candidates for HIV-1 so far have not been able to elicit broadly neutralizing antibodies (bNAbs) although they express the epitopes recognized by bNAbs to the HIV envelope glycoprotein (Env). To understand whether and how Env immunogens interact with the predicted germline versions of known bNAbs, we screened a large panel (N:56) of recombinant Envs (from clades A, B and C) for binding to the germline predecessors of the broadly neutralizing anti-CD4 binding site antibodies b12, NIH45-46 and 3BNC60. Although the mature antibodies reacted with diverse Envs, the corresponding germline antibodies did not display Env-reactivity. Experiments conducted with engineered chimeric antibodies combining the mature and germline heavy and light chains, respectively and vice-versa, revealed that both antibody chains are important for the known cross-reactivity of these antibodies. Our results also indicate that in order for b12 to display its broad cross-reactivity, multiple somatic mutations within its VH region are required. A consequence of the failure of the germline b12 to bind recombinant soluble Env is that Env-induced B-cell activation through the germline b12 BCR does not take place. Our study provides a new explanation for the difficulties in eliciting bNAbs with recombinant soluble Env immunogens. Our study also highlights the need for intense efforts to identify rare naturally occurring or engineered Envs that may engage the germline BCR versions of bNAbs

The development of CD4 binding site antibodies during HIV-1 infection.

Broadly neutralizing antibodies to the CD4 binding site (CD4bs) of gp120 are generated by some HIV-1-infected individuals, but little is known about the prevalence and evolution of this antibody response during the course of HIV-1 infection. We analyzed the sera of 113 HIV-1 seroconverters from three cohorts for binding to a panel of gp120 core proteins and their corresponding CD4bs knockout mutants. Among sera collected between 99 and 258 weeks post-HIV-1 infection, 88% contained antibodies to the CD4bs and 47% contained antibodies to resurfaced stabilized core (RSC) probes that react preferentially with broadly neutralizing CD4bs antibodies (BNCD4), such as monoclonal antibodies (MAbs) VRC01 and VRC-CH31. Analysis of longitudinal serum samples from a subset of 18 subjects revealed that CD4bs antibodies to gp120 arose within the first 4 to 16 weeks of infection, while the development of RSC-reactive antibodies was more varied, occurring between 10 and 152 weeks post-HIV-1 infection. Despite the presence of these antibodies, serum neutralization mediated by RSC-reactive antibodies was detected in sera from only a few donors infected for more than 3 years. Thus, CD4bs antibodies that bind a VRC01-like epitope are often induced during HIV-1 infection, but the level and potency required to mediate serum neutralization may take years to develop. An improved understanding of the immunological factors associated with the development and maturation of neutralizing CD4bs antibodies during HIV-1 infection may provide insights into the requirements for eliciting this response by vaccination